There are 8 US Post Offices in Pickens County serving a total of 96,541 residents equating to 12,068 residents per post office. It's estimated that approximately 154,090 packages are handled across the 8 county post offices annually. Pickens County is a county in the northwest part of the U.S. state of South Carolina. As of the 2010 census, its population was 119,224. Its county seat is Pickens. The county was created in 1826. It is part of the Greenville-Anderson-Mauldin, SC Metropolitan Statistical Area.