There are 4 US Post Offices in Prentiss County serving a total of 28,327 residents equating to 7,082 residents per post office. It's estimated that approximately 45,213 packages are handled across the 4 county post offices annually. Prentiss County is a county located in the U.S. state of Mississippi. As of the 2010 census, the population was 25,275. Its county seat is Booneville. The county is named for Seargent Smith Prentiss, a famous speaker and debater from Natchez, MS. (Seargent was his first name, not a military title)."