There are 22 US Post Offices in Guilford County serving a total of 449,417 residents equating to 20,428 residents per post office. It's estimated that approximately 717,320 packages are handled across the 22 county post offices annually. Guilford County is a county located in the U.S. state of North Carolina. As of the 2010 census, the population was 488,406, making it the third-most populous county in North Carolina. Its seat is Greensboro. Since 1938, an additional county court has been located in High Point, North Carolina. The county was formed in 1771. Guilford County is included in the Greensboro-High Point, NC Metropolitan Statistical Area, which is also included in the Greensboro-Winston-Salem-High Point, NC Combined Statistical Area."