There are 14 US Post Offices in Wayne County serving a total of 44,846 residents equating to 3,203 residents per post office. It's estimated that approximately 71,579 packages are handled across the 14 county post offices annually. Wayne County is the westernmost county in the U.S. state of West Virginia. As of the 2010 census, the population was 42,481. Its county seat is Wayne. The county was founded in 1842 and named for General \"Mad\" Anthony Wayne. Wayne County is part of the Huntington-Ashland, WV-KY-OH Metropolitan Statistical Area, which is also included in the Charleston-Huntington-Ashland, WV-OH-KY Combined Statistical Area.