There are 3 US Post Offices in Ohio County serving a total of 47,965 residents equating to 15,988 residents per post office. It's estimated that approximately 76,557 packages are handled across the 3 county post offices annually. Ohio County is a county located in the Northern Panhandle of the U.S. state of West Virginia. As of the 2010 census, the population was 44,443. Its county seat is Wheeling. The county was formed from the District of West Augusta, Virginia in 1776. It was named for the Ohio River, which forms its western boundary. West Liberty (formerly Black's Cabin) was the county seat from 1777 to 1797. Ohio County is part of the Wheeling, WV-OH Metropolitan Statistical Area."