There are 6 US Post Offices in Wythe County serving a total of 27,803 residents equating to 4,634 residents per post office. It's estimated that approximately 44,377 packages are handled across the 6 county post offices annually. Wythe County is a county located in the U.S. state of Virginia. As of the 2010 census, the population was 29,235. Its county seat is Wytheville."