There are 2 US Post Offices in Cherokee County serving a total of 29,389 residents equating to 14,695 residents per post office. It's estimated that approximately 46,908 packages are handled across the 2 county post offices annually. Cherokee County is a county located in the U.S. state of South Carolina. As of the 2010 census, the population was 55,342. The county seat is Gaffney. The county was formed in 1897 from parts of York, Union, and Spartanburg Counties. It was named for the Cherokee people who historically occupied this area prior to European encounter. Cherokee County comprises the Gaffney, SC Micropolitan Statistical Area, which is also included in the Greenville-Spartanburg-Anderson, SC Combined Statistical Area."