There are 12 US Post Offices in Wilkes County serving a total of 63,894 residents equating to 5,325 residents per post office. It's estimated that approximately 101,982 packages are handled across the 12 county post offices annually. Wilkes County is a county located in the US state of North Carolina. As of the 2010 census, the population was 69,340. In May 2016, the population is almost 69,000. Its county seat is Wilkesboro, and its largest town is North Wilkesboro. Wilkes County comprises the North Wilkesboro, NC Micropolitan Statistical Area."