There are 5 US Post Offices in Cherokee County serving a total of 28,331 residents equating to 5,666 residents per post office. It's estimated that approximately 45,219 packages are handled across the 5 county post offices annually. Cherokee County is the westernmost county in the U.S. state of North Carolina. As of the 2010 census, the population was 27,444. Its county seat is Murphy.