There are 3 US Post Offices in Issaquena County serving a total of 875 residents equating to 292 residents per post office. It's estimated that approximately 1,397 packages are handled across the 3 county post offices annually. Issaquena County is a county located in the U.S. state of Mississippi. As of the 2010 census, the population was 1,406, making it the least populous county east of the Mississippi River. Its county seat is Mayersville. Issaquena County is located in the Mississippi Delta region. The Mississippi River flows along the entire western boundary of the county, and many of the earliest communities were river ports. The county's economy is highly based on agriculture, though a number of hunting camps are also located here and contribute to the economy. Mississippi's two most recent records for the heaviest alligator taken by a hunter have both been in Issaquena County, the latest in 2012 when a 697.5 lb (316.4 kg) alligator was taken at a camp near Fitler."