There are 9 US Post Offices in Pemiscot County serving a total of 17,673 residents equating to 1,964 residents per post office. It's estimated that approximately 28,208 packages are handled across the 9 county post offices annually. Pemiscot County is a county located in the southeastern corner in the Bootheel in the U.S. state of Missouri. As of the 2010 census, the population was 18,296. The largest city and county seat is Caruthersville. The county was officially organized on February 19, 1851, and is named for the local bayou, taken from the Fox dialect word, pem-eskaw, meaning \"liquid mud\". Bordering the Mississippi River and floodplain, the county has been devoted to agricultural development and commodity crops. With mechanization of agriculture, its population has declined since a peak in 1940. Murphy Mound Archeological Site has one of the largest platform mounds in Missouri; it is a major earthwork of the Late Mississippian culture, which had settlement sites throughout the Mississippi Valley and tributaries. The site is privately owned and is not open to the public. The site may have been occupied from as early as 1200 CE and continuing to about 1541.