There are 15 US Post Offices in Tuscola County serving a total of 58,888 residents equating to 3,926 residents per post office. It's estimated that approximately 93,992 packages are handled across the 15 county post offices annually. Tuscola County is a county located in the Thumb region of the U.S. state of Michigan. As of the 2010 census, the population was 55,729. The county seat is Caro. The county was created by Michigan Law on April 1, 1840, from land in Sanilac County and attached to Saginaw County for administrative purposes. The Michigan Legislature passed an act on March 2, 1850, that empowered the county residents to organize governmental functions. Tuscola County is one of five counties that are in the Thumb area. Like the rest of the thumb, Tuscola County enjoys seasonal tourism from larger cities like Flint, Detroit and Saginaw."