There are 1 US Post Offices in Nicholas County serving a total of 7,153 residents equating to 7,153 residents per post office. It's estimated that approximately 11,417 packages are handled across the 1 county post offices annually. Nicholas County is a county located in the U.S. state of Kentucky. As of the 2010 census, the population was 7,135. Its county seat is Carlisle, which is also the only incorporated community in the county. Founded in 1799, the county is named for Col. George Nicholas, the \"Father of the Kentucky Constitution\"."