There are 7 US Post Offices in Greenup County serving a total of 34,087 residents equating to 4,870 residents per post office. It's estimated that approximately 54,407 packages are handled across the 7 county post offices annually. Greenup County is a county located in the U.S. state of Kentucky. As of the 2010 census, the population was 36,910. The county was founded in 1803 and named in honor of Christopher Greenup. Its county seat is Greenup. Greenup County is part of the Huntington-Ashland, WV-KY-OH Metropolitan Statistical Area (MSA), as well as the Charleston-Huntington-Ashland, WV-OH-KY Combined Statistical Area. As of the 2010 census, the MSA had a population of 287,702. New definitions from February 28, 2013 placed the population at 363,000."