There are 9 US Post Offices in Cherokee County serving a total of 21,745 residents equating to 2,416 residents per post office. It's estimated that approximately 34,707 packages are handled across the 9 county post offices annually. Cherokee County (county code CK) is a county located in Southeast Kansas. As of the 2010 census, the county population was 21,603. Its county seat is Columbus, and its most populous city is Baxter Springs."