There are 5 US Post Offices in Cherokee County serving a total of 21,531 residents equating to 4,306 residents per post office. It's estimated that approximately 34,366 packages are handled across the 5 county post offices annually. Cherokee County, Alabama is a county of the U.S. state of Alabama. As of the 2010 census, the population was 25,989. Its county seat is Centre, and it is a prohibition or dry county. The county is named for the Cherokee tribe."